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Over 150 Texas Medical Marijuana Qualifying Conditions
Texas Medical Marijuana Qualifying Conditions are growing. Under today’s Compassionate Use Program, Texans can already qualify for legal, THC relief if they have some forms of chronic pain, PTSD, epilepsy, autism, all cancer-related symptoms, or certain neurodegenerative diseases. qualifying conditions medical marijuana texas
- Starting September 1, 2025, HB 46 will add all chronic pain as a stand-alone diagnosis, traumatic brain injury (TBI), Crohn’s/IBS, hospice/palliative care, and more. A Floweret MD physician can evaluate you online, enter your prescription in the Compassionate Use Registry of Texas (CURT), and update it automatically when the new law takes effect.

To qualify for a medical cannabis prescription in Texas, you must be a permanent resident of the state and have one of the following conditions:
If you do not see your condition listed, such as intestinal spasms, endometrial spasms, glaucoma, schedule a risk-free consultation to discuss whether your symptoms may actually qualify.
HouseBill 46 goes into effect September 1, 2025, and will add more conditions. See bottom of list.
- ALS,
- Alzheimer’s Disease,
- Autism,
- Cerebral Palsy,
- Chronic Pain of 3 months or more (begins 9/1/2025)
- Chronic Traumatic Brain Encephalopathy,
- Epilepsy and other Seizure disorders,
- Huntington’s Disease,
- Multiple Sclerosis,
- Muscular Dystrophy,
- Parkinson’s Disease,
- Peripheral Neuropathies,
- PTSD
- Muscle Spasms/Spasticity,
- Spinal Muscular Atrophy,
- All Cancer
- for full list of *Incurable Neurodegenerative Diseases
- All condition that causes chronic pain of 3 months or more (Sept 1, 2025)
- Traumatic brain injury (TBI) (Sept 1, 2025)
- Crohn’s disease or other inflammatory bowel disease (Sept 1, 2025)
- A terminal illness or any condition for which the patient is receiving hospice or palliative care (Sept 1, 2025)
*The Texas Administrative Code defines an incurable neurodegenerative disease as a condition, injury, or illness: (1) that occurs when nerve cells in the brain or peripheral nervous system lose function over time; and (2) for which there is no known cure.
Full list of Incurable Neurodegenerative Diseases
- 3-hydroxy-3-methylglutaryl-CoA lyase deficiency
- 5-aminoimidazole-4-carboxamide ribonucleotide transformylase deficiency;
- Adenylosuccinate synthase Deficiency
- Alexander disease
- Alpers-Huttenlocher syndrome
- Alpha-fucosidosis
- Alzheimer’s Disease
- Amyloidoses
- Amyotrophic lateral Sclerosis
- Argyrophilic Grain Disease
- Aromatic L-amino acid decarboxylase deficiency
- Asparylglucosaminuria
- Ataxia neuropathy spectrum
- Bidirectional enzyme deficiency
- Canavan disease
- Central Core Muscular Dystrophy
- Cerebral Autosomal Dominant Arteriopathy with Sub-cortical Infarcts and Leukoencephalopathy
- Charcot Marie Tooth and related hereditary neuropathies
- Childhood Myocerebrohepatopathy spectrum
- Chronic Traumatic Encephalopathy
- Congenital Disorders of Glycosylation
- Corticobasal Degeneration
- Creatine Transporter Defect, also known as SLC 6A8
- Creutzfeldt-Jakob Disease
- Dementia with Lewy Bodies
- Deoxyguanisine kinase deficiency
- Dihydropirimidinase DeficiencyDihydropyrimidine dehydrogenase Deficiency
- Dihydropteridine reductase defect
- Duchenne Muscular Dystrophy
- Facioscapulohumeral Muscular Dystrophy
- Familial or Sporadic Fatal Insomnia
- Familial Spastic Paraplegia
- Farber Disease
- Freidreich’s Ataxia
- Frontotemporal dementia and parkinsonism linked to chromosome 17 caused by mutations in MAPT gene
- Frontotemporal Lobar Degeneration
- Galactosemia
- Galactosialidosis
- Gaucher Type 2 and Type 3
- Gerstmann-Straussler-Scheinker Disease
- Globular Glial Tauopathy
- Glutaric acidemia type 1
- Glycine encephalopathy, also known as non-ketotic hyperglycinemia
- Glycogen Storage-Lysosomal: Pompe Disease
- GM1 gangliosidosis
- GM2 gangliosidosis, also known as Tay-Sachs and Sandhoff Disease
- Guanidinoacetate methytransferase deficiency
- Guanosine triphosphate cyclohydrolase deficiency
- Homocysteine re-methylation defects
- Hunter Syndrome
- Hurler Syndrome
- Hypoxanthine-guanine phosophoribosyltransferase Deficiency, also known as Lesch-Nyhan disease
- Kearn Sayers Syndrome
- Krabbe
- Kuru
- L-2-hydroxyglutaric aciduria
- L-Arginine/glycine amidinotransferase deficiency
- Leigh syndrome
- Lesch-Nyhan
- leukodystrophy
- Lewy Body Disorders
- Long-chain L-3 hydroxyacyl-CoA dehydrogenase deficiency
- Lysosomal Storage Diseases
- Mannosidosis
- Manosidosis alpha and beta
- Maple Syrup Urine Disease
- Metachromatic leukodystrophy
- Methylenetetrahydrofolate reductase deficiency severe variant
- Mitochondrial Depletion syndromes types 1 through 14
- Mitochondrial Encephalopathy Lactic Acidosis Stroke
- Mitochondrial Encephalopathy Ragged Red Fiber
- Mitochondrial neurogastrointestinal encephalopathy
- Monoamine oxidase deficiency
- Mucolipidoses
- Mucolipidoses Type II, also known as Inclusion Cell disease
- Mucolipidoses Type III, also known as pseudo-Hurler polydystrophy
- Mucopolysaccaridosis
- Mucopolysaccharidosis Type I, also known as Hurler Syndrome or Scheie Syndrome
- Mucopolysaccharidosis Type II, also known as Hunter Syndrome
- Mucopolysaccharidosis Type III, also known as Sanfilippo A and B
- Mucopolysaccharidosis Type IV, also known as Maroteaux-Lamy
- Mucopolysaccharidosis Type VII, also known as Sly
- Multiple Sulfatase deficiency Myoclonic epilepsy myopathy sensory ataxia
- Multiple System Atrophy
- Neimann Pick Type A and B
- Neimann Pick Type C
- Neonatal Adrenoleukodystrophy
- Neurodegeneration with brain iron accumulation
- Neurofibrillary Tangle dementia, also known as Primary Age-related Tauopathy
- Neuronal ceroid lipofuscinosis types 1-10 including Batten Disease
- Neuropathy, Ataxia, and Retinitis Pigmentosa
- Oligosaccharidoses
- Pantothenate Kinase Associated Neurodegeneration
- Parkinson’s Disease
- Pelizaeus-Merzbacher disease
- Peripheral neuropathy types 1 through 4
- Peroxisomal biosynthesis defects
- Pick Disease
- Polyol disorders
- Pompe Disease
- Primary Age-related Tauopathy
- Primary Lateral Sclerosis
- Prion Diseases
- Progressive Choreas: Huntington’s Disease
- Progressive dystonias DYT genes 1 through 20
- Progressive Muscular Atrophy
- Progressive Supranuclear Palsy
- Pterin-4-carbinolamine dehydratase defect
- Pyruvate Carboxylase Deficiency
- Pyruvate Dehydrogenase Deficiency
- Pyruvoyl-tetahydropterin synthase defect
- Refsum Disease
- Respiratory chain disorders complex 1 through 4 defects: Co Q biosynthesis defects
- RRM2B-related mitochondrial disease
- Salidosis
- Sandhoff Disease
- Sanfilippo A and B
- Scheie Syndrome
- Schindler
- Segawa Diease, also known as Dopamine Responsive Dystonia
- Sepiapterin reductase defect
- Sialidosis
- SLC 6A8
- Sly
- Spinal Muscular Atrophy
- Spinal-bulbar muscular atrophy
- Spinocerebellar ataxia
- Subacute necrotizing encephalopathy, also known as Leigh syndrome
- SUCLG1-related mitochondrial DNA depletion syndrome, encephalomyopathic form with methylmalonic aciduria
- Tay-Sachs
- Thymidine Kinase
- Transactive response DNA-binding protein-43 (TDP-43) Proteinopathies
- Trifunctional protein deficiency
- Vascular dementia
- Wilson Disease
- X-linked adrenoleukodystrophy
- Zellweger syndrome
A treating physician of a patient suffering from an incurable neurodegenerative disease not listed in subsection (b) of this section may submit a request to the department to have a disease added.
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